Generic medicine, the differences of concentration in the blood!!
 |
generic medicines |
One of the critical points is that the concentration of the generic medicine and therapeutically useful in the blood can have important fluctuations. The generic medicine comes to life when the patents of branded products expire and everyone can copy them on condition that they respect a set of rules. The generic drug is subject to approval like everyone else, and must demonstrate equivalence than its originator. It must contain the prescribed amount of the active ingredient and must document, by pharmaceutical studies (which are conducted in healthy volunteers, editor’s note), which achieves adequate concentrations in the blood to exert its therapeutic effect.
 |
generic drugs |
One of the critical points is that the therapeutically useful concentration of the generic medicine in the blood can have important fluctuations. Generic drugs are an irreplaceable resource; however, care must be taken to some elements, so that their use is correct, effective and safe. The bioavailability of a generic blood can vary by up to 20 percent more or less than the originator: a range of 40 percent for some diseases that cannot be tolerable, as for example in cardiac arrhythmias where therapy should be measured and modulated with much precision for maximum effectiveness with fewer side effects, the objectors must demonstrate that there is a different therapeutic effect related to this variability.
generic medicines
And then it tolerates that the active ingredient has the originator has a variability in the blood between 85 and 120 percent. The fluctuation of the generic medicine in the blood does not depend only on the medicine itself, but also the patient's condition: its weight, the diet that follows, by the presence of other diseases and so on.
In medications then there are also the recipients. They are inert substances that do not have therapeutic properties: their function is to make the active ingredient administered, that is, the component of the tablet which performs a therapeutic function. The used for generic ingredients are still the same as those in brand-name drugs. The other ingredients in generic medicine can change, but does not affect its effectiveness. Allergies can be, but this is also a risk associated with the reference product, i.e. drug branded. But again clinicians observe that the recipients (variables from generic to generic), may change the absorption, bioavailability and ultimately the action of the medicinal product.
